Recent Case Studies
Hemocompatiblity of Polyurethane catheters in Adult Rabbits
This study was designed to test new drug targets proposed to enhance hemocompatibility of commonly used intravenous polyurethane catheters. For this project, 5 different kinds of catheters were implanted in the superior vena cava of adult rabbits for extended time points. End points included survival and morbidity observations as well as gross, biochemical and microscopic observations of inflammation.
Purification of human Urokinase from kidney cell line
Urokinase is a potent thrombolytic agent used for therapeutic purposes in clinical settings. Traditionally, human urokinase is purified from urine samples. We have developed a novel technique of maintaining a human kidney cell line in culture for extended periods of time, and then purifying urokinase from the cell culture supernatant to desired purity (Ref.). Using this method, we can isolate protein with high specific activity and can achieve 75-85% purity. This technique is highly adaptable and can used for culturing many different types of cells.
Assessment of biomaterial sensitivity in adult rats
This was a blinded study to determine biosafety of newly developed polymer materials. For this project, subcutaneous catheters fabricated from 4 different types of new biomaterials were implanted sub-cutaneouly and a time-dependent response to these implantations was studied. End points included sensitivity and inflammation analysis, at gross, biochemical and microscopic levels.
Assessment of drug interactions and functions in rabbits
This is a blinded proposal to evaluate possible drug targets in terms of their efficacy, half life and drug interactions in urinary infections. The model we have standardized for our client is of adult rabbits challenged with bacterial infections. The drugs are administered via coated urinary catheters implanted for various time points.
Development of smart polymeric biomaterials
This research project aims to develop self-assembling biological structures and polymers that can be used for bioseparation, drug delivery, biosensors, cell sheet engineering and cell culture technologies. We have been successful in designing new superporous hydrogels that are being used for cultivation of cells and development of integrated bioprocess for the product recovery.
All studies are carried out in our partner laboratories, which are NABL accredited for chemical and biological testing as per ISO/IEC 17025 guidelines. Our partners also have their own NIH-accredited animal housing facilities.